Product Type > Antibodies > Primary Antibodies > Monoclonal Antibodies

GRM1 Rabbit mAb (A11890)

Datasheet SDS

Tested applications: WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra) ELISA MeDIP Nucleotide Array DB FACS CoIP FCM CUT&Tag meRIP Inhibition

Reactivity:Human, Mouse, Rat

ABclonal:Western blot - GRM1 Rabbit mAb (A11890)

Western blot analysis of extracts of various cell lines, using GRM1 antibody (A11890).
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.

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Overview

Product name GRM1 Rabbit mAb
Catalog No. A11890
Host species Rabbit
Purification method Affinity purification
Isotype IgG

Background

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

Immunogen information

Immunogen Recombinant protein of human GRM1
Sequence Email for sequence
Gene ID 2911
Swiss prot Q13255
Synonyms MGLU1; SCA44; GPRC1A; MGLUR1; SCAR13; PPP1R85; GRM1
Calculated MW 132kDa
Observed MW 132kDa

Applications

Reactivity Human, Mouse, Rat
Tested applications WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra) ELISA MeDIP Nucleotide Array DB FACS CoIP FCM CUT&Tag meRIP Inhibition
Recommended dilution
  • WB 1:500 - 1:2000
  • IHC-P 1:50 - 1:100
  • IF/ICC 1:50 - 1:100
  • IP 1:20 - 1:50
Storage buffer Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application key Western blotting    Immunohistochemistry    Immunofluorescence    Immunoprecipitation    
Positive samples Neonatal Mouse brain, Rat brain
Cellular location Cell membrane, Multi-pass membrane protein

Research Area

GRM1 Rabbit mAb images

ABclonal:Western blot - GRM1 Rabbit mAb (A11890)}

Western blot - GRM1 Rabbit mAb (A11890)

Western blot analysis of extracts of various cell lines, using GRM1 antibody (A11890).
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.

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Related Targets

Based on existing publications, the following genes are closely related to research on GRM1. (Numbers indicate number of published articles where both targets appear.)

1/

Related Research Area

Based on existing publications, the following research topics are related to GRM1. (Distance between topics and target gene indicate popularity.) GRM1

* Data provided by citexs.com, for reference only.

Publishing research using A11890? Please let us know so that we can cite the reference in this datasheet.

Antibodies (3)

Secondary Antibodies (23)

* For research use only. Not for therapeutic or diagnostic purposes.

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